Publikációk
Broca-Brisson L, Harati R, Disdier C, Mozner O, Gaston-Breton R, Maïza A, Costa N, Guyot AC, Sarkadi B, Apati A, Skelton MR, Madrange L, Yates F, Armengaud J, Hamoudi R, Mabondzo A. Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency. Elife. 2023 Oct 13;12:RP88459. doi: 10.7554/eLife.88459. PMID: 37830910; PMCID: PMC10575631.
Reé D, Borsy A, Fóthi Á, Orbán TI, Várady G, Erdei Z, Sarkadi B, Réthelyi J, Varga N, Apáti Á. Establishing a human embryonic stem cell clone with a heterozygous mutation in the DGCR8 gene. Stem Cell Res. 2020 Dec 22;50:102134. doi: 10.1016/j.scr.2020.102134. Epub ahead of print. PMID: 33360445.
Kovacsics D, Brózik A, Tihanyi B, Matula Z, Borsy A, Mészáros N, Szabó E, Németh E, Fóthi Á, Zámbó B, Szüts D, Várady G, Orbán TI, Apáti Á, Sarkadi B. Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells. Biochem Pharmacol. 2020 May;175:113865. doi: 10.1016/j.bcp.2020.113865. Epub 2020 Mar 4. PMID: 32142727.
Oláh A, Ruppert M, Orbán TI, Apáti Á, Sarkadi B, Merkely B, Radovits T. Hemodynamic characterization of a transgenic rat strain stably expressing the calcium sensor protein GCaMP2. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1224-H1228. doi: 10.1152/ajpheart.00074.2019. Epub 2019 Mar 15. PMID: 30875251.
Apáti Á, Varga N, Berecz T, Erdei Z, Homolya L, Sarkadi B. Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity. Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):61-75. doi: 10.1080/17425255.2019.1558207. Epub 2018 Dec 17. PMID: 30526128.
Erdei Z, Schamberger A, Török G, Szebényi K, Várady G, Orbán TI, Homolya L, Sarkadi B, Apáti Á. Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells. PLoS One. 2018 Apr 12;13(4):e0194925. doi: 10.1371/journal.pone.0194925. PMID: 29649238; PMCID: PMC5896897.
Vőfély G, Berecz T, Szabó E, Szebényi K, Hathy E, Orbán TI, Sarkadi B, Homolya L, Marchetto MC, Réthelyi JM, Apáti Á. Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein. Mol Cell Neurosci. 2018 Apr;88:222-230. doi: 10.1016/j.mcn.2018.02.003. Epub 2018 Feb 6. PMID: 29425968.
Pálóczi J, Varga ZV, Apáti Á, Szebényi K, Sarkadi B, Madonna R, De Caterina R, Csont T, Eschenhagen T, Ferdinandy P, Görbe A. Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury. Oxid Med Cell Longev. 2016;2016:4298945. doi: 10.1155/2016/4298945. Epub 2016 Jun 15. PMID: 27403231; PMCID: PMC4925993.
Sándor S, Jordanidisz T, Schamberger A, Várady G, Erdei Z, Apáti Á, Sarkadi B, Orbán TI. Functional characterization of the ABCG2 5′ non-coding exon variants: Stem cell specificity, translation efficiency and the influence of drug selection. Biochim Biophys Acta. 2016 Jul;1859(7):943-51. doi: 10.1016/j.bbagrm.2016.05.007. Epub 2016 May 15. PMID: 27191194.
Apáti Á, Berecz T, Sarkadi B. Calcium signaling in human pluripotent stem cells. Cell Calcium. 2016 Mar;59(2-3):117-23. doi: 10.1016/j.ceca.2016.01.005. Epub 2016 Feb 17. PMID: 26922096.
Apáti Á, Szebényi K, Erdei Z, Várady G, Orbán TI, Sarkadi B. The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation. Expert Opin Drug Metab Toxicol. 2016;12(1):77-92. doi: 10.1517/17425255.2016.1121382. Epub 2015 Dec 14. PMID: 26592535.
Szebényi K, Füredi A, Kolacsek O, Pergel E, Bősze Z, Bender B, Vajdovich P, Tóvári J, Homolya L, Szakács G, Héja L, Enyedi Á, Sarkadi B, Apáti Á, Orbán TI. Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling. Sci Rep. 2015 Aug 3;5:12645. doi: 10.1038/srep12645. PMID: 26234466; PMCID: PMC4522653.
Erdélyi-Belle B, Török G, Apáti Á, Sarkadi B, Schaff Z, Kiss A, Homolya L. Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells. Pathol Oncol Res. 2015 Sep;21(4):1059-70. doi: 10.1007/s12253-015-9936-5. Epub 2015 Apr 7. PMID: 25845432.
Bacskai I, Mázló A, Kis-Tóth K, Szabó A, Panyi G, Sarkadi B, Apáti Á, Rajnavölgyi É. Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells. Stem Cells Dev. 2015 Aug 1;24(15):1805-16. doi: 10.1089/scd.2014.0509. Epub 2015 Apr 29. PMID: 25808140.
Szebényi K, Füredi A, Kolacsek O, Csohány R, Prókai Á, Kis-Petik K, Szabó A, Bősze Z, Bender B, Tóvári J, Enyedi Á, Orbán TI, Apáti Á, Sarkadi B. Visualization of Calcium Dynamics in Kidney Proximal Tubules. J Am Soc Nephrol. 2015 Nov;26(11):2731-40. doi: 10.1681/ASN.2014070705. Epub 2015 Mar 18. PMID: 25788535; PMCID: PMC4625667.
Kolacsek O, Erdei Z, Apáti A, Sándor S, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI. Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons. Hum Gene Ther Methods. 2014 Aug;25(4):241-52. doi: 10.1089/hgtb.2013.149. PMID: 25045962; PMCID: PMC4142840.
Szebényi K, Péntek A, Erdei Z, Várady G, Orbán TI, Sarkadi B, Apáti Á. Efficient generation of human embryonic stem cell-derived cardiac progenitors based on tissue-specific enhanced green fluorescence protein expression. Tissue Eng Part C Methods. 2015 Jan;21(1):35-45. doi: 10.1089/ten.TEC.2013.0646. PMID: 24734786; PMCID: PMC4291086.
Erdei Z, Lőrincz R, Szebényi K, Péntek A, Varga N, Likó I, Várady G, Szakács G, Orbán TI, Sarkadi B, Apáti A. Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives. Cytometry B Clin Cytom. 2014 Sep;86(5):299-310. doi: 10.1002/cyto.b.21168. Epub 2014 Apr 11. PMID: 24729538.
Apáti Á, Pászty K, Hegedűs L, Kolacsek O, Orbán TI, Erdei Z, Szebényi K, Péntek A, Enyedi Á, Sarkadi B. Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein. Cell Signal. 2013 Apr;25(4):752-9. doi: 10.1016/j.cellsig.2012.12.024. Epub 2013 Jan 7. PMID: 23305950.
Erdei Z, Sarkadi B, Brózik A, Szebényi K, Várady G, Makó V, Péntek A, Orbán TI, Apáti Á. Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response. Eur Biophys J. 2013 Mar;42(2-3):169-79. doi: 10.1007/s00249-012-0838-0. Epub 2012 Aug 1. PMID: 22851001.
Varga N, Veréb Z, Rajnavölgyi E, Német K, Uher F, Sarkadi B, Apáti A. Mesenchymal stem cell like (MSCl) cells generated from human embryonic stem cells support pluripotent cell growth. Biochem Biophys Res Commun. 2011 Oct 28;414(3):474-80. doi: 10.1016/j.bbrc.2011.09.089. Epub 2011 Sep 24. PMID: 21971558.
Apáti Á, Pászty K, Erdei Z, Szebényi K, Homolya L, Sarkadi B. Calcium signaling in pluripotent stem cells. Mol Cell Endocrinol. 2012 Apr 28;353(1-2):57-67. doi: 10.1016/j.mce.2011.08.038. Epub 2011 Sep 14. PMID: 21945604.
Szebényi K, Erdei Z, Péntek A, Sebe A, Orbán TI, Sarkadi B, Apáti Á. Human pluripotent stem cells in pharmacological and toxicological screening: new perspectives for personalized medicine. Per Med. 2011 May;8(3):347-364. doi: 10.2217/pme.11.19. PMID: 29783530.
Kolacsek O, Krízsik V, Schamberger A, Erdei Z, Apáti A, Várady G, Mátés L, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI. Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers. Mob DNA. 2011 Mar 3;2(1):5. doi: 10.1186/1759-8753-2-5. Erratum in: Mob DNA. 2013 Mar 15;4(1):11. PMID: 21371313; PMCID: PMC3060107.
Sarkadi B, Orbán TI, Szakács G, Várady G, Schamberger A, Erdei Z, Szebényi K, Homolya L, Apáti A. Evaluation of ABCG2 expression in human embryonic stem cells: crossing the same river twice? Stem Cells. 2010 Jan;28(1):174-6. doi: 10.1002/stem.262. PMID: 19924769.
Orbán TI, Apáti A, Németh A, Varga N, Krizsik V, Schamberger A, Szebényi K, Erdei Z, Várady G, Karászi E, Homolya L, Német K, Gócza E, Miskey C, Mátés L, Ivics Z, Izsvák Z, Sarkadi B. Applying a „double-feature” promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery. Stem Cells. 2009 May;27(5):1077-87. doi: 10.1002/stem.45. PMID: 19415778.
Apáti A, Orbán TI, Varga N, Németh A, Schamberger A, Krizsik V, Erdélyi- Belle B, Homolya L, Várady G, Padányi R, Karászi E, Kemna EW, Német K, Sarkadi B. High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta. 2008 Dec;1778(12):2700-9. doi: 10.1016/j.bbamem.2008.08.010. Epub 2008 Aug 20. PMID: 18793608.